1-Benzylpiperazine → 1-Benzyl-4-(benzothiophen-2-yl)piperazine

HRID 481959ノート

反応式

HRID 481959 の反応式
S[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[CH:6]=1.[CH2:11]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1(C)C=CC=CC=1>[CH2:11]([N:18]1[CH2:23][CH2:22][N:21]([C:2]2[S:3][C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=3[CH:6]=2)[CH2:20][CH2:19]1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

参加物

4

反応物 2

HCID 759941-BenzylpiperazineHCID 11073791Benzo[b]thiophene-2-thiol

生成物 1

HCID 217016231-Benzyl-4-(benzothiophen-2-yl)piperazine収率 46.5%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of 2-mercaptobenzothiophene (1.8 g, 10.8 mmol) in toluene under nitrogen was added N-benzylpiperazine (1.88 ml, 10.8 mmol) and the mixture heated at reflux for 1.5 h. Left to cool, concentrated in vacuo and product recrystallised from diethyl ether-hexane to yield the title compound (1.55 g), m.p. 160°-161° C.

後処理

  1. temperaturethe mixture heated
  2. temperatureat reflux for 1.5 h
  3. waitLeft
  4. temperatureto cool
  5. concentrationconcentrated in vacuo and product
  6. customrecrystallised from diethyl ether-hexane

出典と根拠

ORDレコード
ord-1752c34019b44edc9e735b4d3cbefc7f
出典データセット
uspto-grants-1998_08
特許番号
US05792768

反応ノート

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