反应详情

A mixture of 3-methylsulfanyl-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate (0.5 g), octylamine (0.5 mL) and m-chlorotoluene (3 mL) was refluxed for 2-3 h (until completion of the reaction; t.l.c.). Most of the solvents were removed by distillation and the residue was dispersed in a mixture of water (30 mL) and methanol (30 mL) and supplemented with NaOH 10% w/v in water (2 mL). The mixture was treated with charcoal, filtered, and the filtrate was adjusted to pH 6 with 1N HCl. The resulting precipitate was collected by filtration, washed with water and dried (yield: 0.29 g); m.p. 176°-179° C. (Compound 13).

1. temperaturewas refluxed for 2-3 h (
2. customuntil completion of the reaction
3. customMost of the solvents were removed by distillation
4. additionthe residue was dispersed in a mixture of water (30 mL) and methanol (30 mL)
5. additionThe mixture was treated with charcoal
6. filtrationfiltered
7. filtrationThe resulting precipitate was collected by filtration
8. washwashed with water
9. customdried (yield: 0.29 g)