Diethyl Ether → HCID 178481249, compound

HRID 481971Notes

Reaction equation

HRID 481971 reaction equation
[CH3:1][N:2]1[C:7](SC)=[N:6][C:5]2[CH:10]=[CH:11][N:12]=[CH:13][C:4]=2[S:3]1(=[O:15])=[O:14].[CH2:16]([NH2:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.CCOCC>O1CCOCC1>[CH2:16]([NH:23][C:7]1[N:2]([CH3:1])[S:3](=[O:15])(=[O:14])[C:4]2[CH:13]=[N:12][CH:11]=[CH:10][C:5]=2[N:6]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 7504BenzylamineHCID 15449265HCID 15449265, compound

Product 1

HCID 178481249HCID 178481249, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 2-methyl-3-methylsulfanyl-2H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (0.5 g) and benzylamine (0.5 mL) in dioxane (2.5 mL) was refluxed until completion of the reaction (t.l.c.). After cooling, the addition of ether gave rise to the precipitation of the title compound. The precipitate was collected by filtration, washed with ether and recrystallized from methanol-ether (yield: 0.4 g); m.p. 142°-146° C. (Compound 20).

Workup

  1. temperatureAfter cooling
  2. customgave rise
  3. customto the precipitation of the title compound
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with ether
  6. customrecrystallized from methanol-ether (yield: 0.4 g)

Sources & evidence

ORD record
ord-73ca2225972e4a5f910440751f8c278e
Source dataset
uspto-grants-1998_08
Patent number
US05792764

Reaction notes

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