HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 19065073, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Ethylamine hydrochloride | HCID 11198 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 2-[4-Chloro-2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]phenoxy]acetic acid | HCID 54072365 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 19065073 | HCID 19065073 | — |
Reaction Steps
EDC Hydrochloride (249 mg, 1.3 mmol) was added to a stirred mixture of 2-t-butoxycarbonylaminomethyl-4-chlorophenoxyacetic acid (316 mg, 1.0 mmol), HOBT (176 mg, 1.3 mmol), ethylamine hydrochloride (106 mg, 1.3 mmol) and N-methylmorpholine (0.396 ml, 3.6 mmol) in DMF (4 ml) and the mixture was stirred for 16 h. The reaction was partitioned between ethylacetate and 5% KHSO4 solution and the organic layer was washed with 5% KHSO4 solution, water, NaHCO3 solution and brine, dried (Na2SO4) and evaporated in vacuo to a solid (333 mg) which was used for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05792779 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-ce6fb1e6bd584ae6974f8f60ba16b189 |
| Source note | uspto-grants-1998_08 |