HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 482022Generated: October 27, 2026
Sodium Hydroxide → (2-(5-Chloro-2-methoxybenzoylamino)ethyl]-5-(methylaminocarbonylaminosulfonyl)thiophene
https://huagongshe.com/reaction/482022
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,2,2-Trichloro-n-methylacetamide | HCID 248652 | — |
| Reactant | 2-[2-(5-Chloro-2-methoxybenzoylamino)ethyl]-5-sulfamoylthiophene | HCID 15288672 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (2-(5-Chloro-2-methoxybenzoylamino)ethyl]-5-(methylaminocarbonylaminosulfonyl)thiophene | HCID 9802837 | — |
Reaction Steps
120 mg of powdered NaOH and 141 mg of N-methyltrichloro-acetamide (0.8 mmol) were added to 299 mg (0.8 mmol) of 2-[2-(5-chloro-2-methoxybenzoylamino)ethyl]-5-sulfamoyl-thiophene in 9 ml of DMSO. The mixture was stir 65° C. for 1.5 hours. After cooling, it was stirred into ice water of pH 2. The precipitate was filtered off with suction and taken up in CH2Cl2, and the solution was washed with water and dried using MgSO4. After evaporating the solvent, a yellow-brown crude product remained which, after treatment with CH2Cl2 /5% methanol, crystallized at -4° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05792788 |
|---|
| Source dataset | uspto-grants-1998_08 |
|---|
| ORD ID | ord-16b3842ff8724a55bc81d390fd245322 |
|---|
| Source note | uspto-grants-1998_08 |
|---|
