HCID 19065178, compound → HCID 15288675, compound

Participants

Reaction Steps

311 mg (0.8 mmol) of 2-[2-(5-chloro-2-methoxybenzoyl-amino)ethyl]-3-methyl-5-sulfamoylthiophene were treated with 448 mg of KOCN and 0.6 ml of triethylamine, and the mixture was then heated to reflux for 4 h. The cooled solution was filtered and evaporated to dryness. The residue was stirred with 40 ml of H2O, 25 ml of triethylamine and 25 ml of ethyl acetate. The organic phase was extracted 3 times with water/1% triethylamine. The combined aqueous phases were acidified with 2N hydrochloric acid. The precipitate formed was stirred for 3 hours in an ice bath and filtered off with suction.

Provenance & Evidence