HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 482025Generated: October 30, 2026
Hydrochloric Acid → 2-[2-(5-Chloro-2-methoxybenzoylamino)ethyl]-5-(methyl-aminothiocarbonylaminosulfonyl)thiophene
https://huagongshe.com/reaction/482025
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | 2-[2-(5-Chloro-2-methoxybenzoylamino)ethyl]-5-sulfamoylthiophene | HCID 15288672 | — |
| Product | 2-[2-(5-Chloro-2-methoxybenzoylamino)ethyl]-5-(methyl-aminothiocarbonylaminosulfonyl)thiophene | HCID 86753009 | — |
Reaction Steps
375 mg of 2-[2-(5-chloro-2-methoxybenzoylamino)ethyl]-5-sulfamoylthiophene were dissolved in 3 ml of absolute DMF together with 415 mg of K2 CO3 and 90 mg of methyl isothiocyanate, and the mixture was then stirred for 3 h at 60° C. The cooled solution was introduced into 2N HCl and the resulting precipitate was filtered off with suction. The dried residue was chromatographed on silica gel using the eluent system ethyl acetate/toluene 1:1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05792788 |
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| Source dataset | uspto-grants-1998_08 |
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| ORD ID | ord-357659a0086b4f10a5b8ee590c545277 |
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| Source note | uspto-grants-1998_08 |
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