HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 482029Generated: October 30, 2026
Oxindole → 3-[(4-Methylthiophen-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
https://huagongshe.com/reaction/482029
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxindole | HCID 321710 | — |
| Reactant | 4-methylthiophene-2-carbaldehyde | HCID 2795526 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-[(4-Methylthiophen-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one | HCID 69631704 | 61.1% |
Reaction Steps
A reaction mixture of 133.0 mg of oxindole, 151.2 mg of the 4-methylthiophene-2-carboxaldehyde, and 3 drops of piperidine in 3 mL of ethanol was stirred at 90° C. for 3 h. After cooling, the precipitate was filtered, washed with cold ethanol, and dried to yield 147.3 mg (61%) of the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05792783 |
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| Source dataset | uspto-grants-1998_08 |
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| ORD ID | ord-8a9e9512ad334afb98832c9bec13c9c7 |
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| Source note | uspto-grants-1998_08 |
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