8-Bromo-1,2,3,4-tetrahydro-2-methyl-6-nitro-5-isoquinolinamine → 8-Bromo-1,2,3,4-tetrahydro-2-methyl-5,6-isoquinolinediamine

Participants

Reaction Steps

A solution of the product from Example 10 (0.78 g, 2.73 mmol) in 100 mL of THF was treated with Raney nickel (1.0 g) and hydrogenated for 1.5 hours at room temperature. The reaction mixture was filtered and concentrated to give the title compound as a tan solid (0.63 g, 90%).

Provenance & Evidence