HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-ethyl-5-bromo-8-nitrotetrahydroisoquinoline → N-ethyl-5-bromo-8-aminotetrahydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-ethyl-5-bromo-8-nitrotetrahydroisoquinoline | HCID 69895026 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-ethyl-5-bromo-8-aminotetrahydroisoquinoline | HCID 69894940 | — |
Reaction Steps
Raney nickel was refluxed in acetone for 2 hours prior to use to deactivate the metal. The product from Example 26 (0.1 g, 0.35 mmol) was dissolved in THF (10 mL), the Raney nickel added, and the reaction vessel charged with hydrogen gas. After stirring for 1 hour, the Raney nickel was removed by filtration and the solvent removed by filtration to give N-ethyl-5-bromo-8-aminotetrahydroisoquinoline (used without further purification).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06703391B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-88d85bad3d2548ecb739e754cda72ea3 |
| Source note | uspto-grants-2004_03 |