HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Nitroquinolin-5-ylamine → Quinoline-5,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Nitroquinolin-5-ylamine | HCID 118901 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Quinoline-5,6-diamine | HCID 426874 | — |
Reaction Steps
A solution of 5-amino-6-nitroquinoline (25 g, 0.13 mol) in THF (500 mL) and methanol (500 mL) was treated with Raney nickel (7 g) under a hydrogen atmosphere (50.4 psi) on a Parr apparatus for 3.4 hours. Standard work-up gave the 5,6-diaminoquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06703391B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-7254d1bc18134c949e814f0cd113c64c |
| Source note | uspto-grants-2004_03 |