1-Butanol → HCID 240120, compound

Participants

Reaction Conditions

Reaction Steps

In a 100-ml three-necked flask, 24 g (0.2 mole) of phenylacetaldehyde, 18 g (0.24 mole) of n-butanol, 10 g of anhydrous magnesium sulfate and 0.1 mg of stannous chloride dihydrate were charged. The resulting mixture was stirred at 100° C. under atmospheric pressure for 6 hours in a nitrogen atmosphere. After the removal of magnesium sulfate, the residue was purified by chromatography on a silica gel column to give 43.1 g of phenylacetaldehyde dibutyl acetal [R1 =a benzyl group, R2 =a hydrogen atom and R3 =an n-butyl group] (yield: 86.3%).

Provenance & Evidence