Chlorosulfonic acid → 6-(Chlorosulfonyl)-1,7,8,9-tetrahydro-8-methyl-2H-pyrrolo[3,4-f]quinoxaline-2,3(4H)-dione

HRID 48217Notes

Reaction equation

HRID 48217 reaction equation
[CH3:1][N:2]1[CH2:14][C:13]2[CH:12]=[CH:11][C:10]3[NH:9][C:8](=[O:15])[C:7](=[O:16])[NH:6][C:5]=3[C:4]=2[CH2:3]1.[Cl:17][S:18](O)(=[O:20])=[O:19]>>[Cl:17][S:18]([C:12]1[C:13]2[CH2:14][N:2]([CH3:1])[CH2:3][C:4]=2[C:5]2[NH:6][C:7](=[O:16])[C:8](=[O:15])[NH:9][C:10]=2[CH:11]=1)(=[O:20])=[O:19]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 101306261,7,8,9-tetrahydro-8-methyl-2H-pyrrolo[3,4-f]quinoxaline-2,3(4H)-dione

Product 1

HCID 227424926-(Chlorosulfonyl)-1,7,8,9-tetrahydro-8-methyl-2H-pyrrolo[3,4-f]quinoxaline-2,3(4H)-dione

Procedure

A solution of 1,7,8,9-tetrahydro-8-methyl-2H-pyrrolo[3,4-f]quinoxaline-2,3(4H)-dione in chlorosulfonic acid was stirred at 120° C. for 3 hours, whereafter it was cooled and poured on ice. This afforded a crystalline precipitate of the product, which was filtered off and washed with water, mp>300° C.

Workup

  1. temperaturewas cooled
  2. additionpoured on ice
  3. customThis afforded a crystalline precipitate of the product, which
  4. filtrationwas filtered off
  5. washwashed with water, mp>300° C.

Sources & evidence

ORD record
ord-17ac3bacb25a4d7096ab42d16b38ea72
Source dataset
uspto-grants-2004_03
Patent number
US06703391B2

Reaction notes

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