Pyridine → HCID 19063395, compound

Participants

Reaction Steps

1,3-Propanediol (1.053 g, 13.84 mmol), trityl chloride (3.50 g, 12.6 mmol) and anhydrous pyridine (5 ml) were combined in a flame-dried round-bottomed flask. The reaction mixture was stirred overnight at room temperature. Ether was added to the reaction mixture and the solution was extracted with H2O, 1N HCl, H2O, and brine. The ether layer was dried (MgSO4) and the solvent removed under reduced pressure. The crude product was purified by column chromatography (100 g silica gel; hexanes:ethyl acetate, gradient 8:1 to 6:1) to provide the pure ether compound 20, 1-O-trityloxy-propanol (1.85 g, 46.4% yield).

Provenance & Evidence