HCID 86754148, compound → HCID 21711985, compound

Participants

Reaction Conditions

Reaction Steps

Methylene bis(16-triphenylmethoxyhexadecanoate) (0.07g, 0.07 mmol) from Example 1b(iii) above was dissolved in glacial acetic acid (8 ml) and heated at 55° C. The reaction was monitored by TLC. After 10 hours the reaction mixture was poured onto ice, and the crude product was filtered, washed with aqueous sodium bicarbonate and water, and dried under reduced pressure. The product was purified by flash chromatography on a silica column with chloroform/methanol (20:1) as eluent to yield the title compound as a white solid.

Provenance & Evidence