Hydrogen Sulfide → HCID 19063817, compound

Participants

Reaction Steps

Hydrogen sulfide was passed into a solution of 1.5 g (3.7 mmol) 3-cyanobenzenesulfonic acid-3-methyl-5-[2-(pyridazin-4-ylamino)-ethoxy]-phenyl ester (example 9) and 2.0 ml triethylamine in 20 ml pyridine until saturation (ca. 30 min). After 2 h at room temperature the solvent was removed in a vacuum, the residue was admixed with water, extracted with ethyl acetate, the solvent was removed in a vacuum, the residue was taken up in methanol and filtered over silica gel (dichloromethane: methanol=98:2). The solvent was removed in a vacuum and the title compound was obtained in a 87% yield as yellow crystals of Fp 76°-78° C.

Provenance & Evidence