HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 5-Bromo-8-ethoxalylaminoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Acetic acid, oxo(8-quinolinylamino)-, ethyl ester | HCID 10421911 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Bromo-8-ethoxalylaminoquinoline | HCID 4774423 | 88.7% |
Reaction Steps
A solution of the product from Example 81 (20 g, 82 mmol) in 200 mL acetic acid was treated with a solution of bromine (15.7 g, 0.198 mol) in 50 mL of acetic acid and stirred at room temperature for 1 hour. The solid was collected by filtration and washed with ether to give the title compound (23.5 g, 69% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06703391B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-71bba429e0e8404387f2859a3b786732 |
| Source note | uspto-grants-2004_03 |