HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 9-(2-Methanesulfonyloxyethyl)-2,4-di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 2-[2,4-Di(pyrrolidin-1-yl)-9H-pyrimido[4,5-b]indol-9-yl]ethan-1-ol | HCID 15521616 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 9-(2-Methanesulfonyloxyethyl)-2,4-di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indole | HCID 53732408 | — |
Reaction Steps
A mixture of methanesulfonyl chloride (0.38 mL) in methylene chloride (20 mL) is added dropwise to a mixture of 9-(2-hydroxyethyl)-2,4-di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indole (VIII, EXAMPLE3, 1.05 g) and triethylamine (0.5 mL) in methylene chloride (25 mL). After a few minutes, the reaction mixture is diluted with water and extracted with methylene chloride. The organic layer is dried (sodium sulfate) and concentrated, to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05795986 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-1c1ac541387f4527b46d1695d7932ec6 |
| Source note | uspto-grants-1998_08 |