Hydrochloric Acid → HCID 67699230, compound

Participants

Reaction Steps

A hot solution of 9-[2--(3-Oxo-4-morpholinyl)ethyl]-2,4-di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indole (XIII, EXAMPLE30, 0.91 g, 2.1 mmol) in ethanol (60 mL) is treated with aqueous hydrochloric acid (5M, 0.43 mL, 2.15 mmol). The mixture is cooled to 20°-250° and concentrated under reduced pressure to a solid. Recrystallization of the solid from acetone/methanol/ether gives the title compound, mp=210°-213°; IR (mull) 1651, 1631, 1573, 1554, 1527, 1499, 1486, 1436, 1415, 1353, 1339, 1312, 1241, 1110 and 772 cm-1. ##STR9##

Provenance & Evidence