[Butyl(1,2,3,4-tetrahydro-6-nitro-5-quinolinyl)-amino]oxo-acetic Acid Ethyl Ester → HCID 20633122, compound

HRID 48234Notes

Reaction equation

HRID 48234 reaction equation
C([O:3][C:4](=O)[C:5]([N:7]([CH2:21][CH2:22][CH2:23][CH3:24])[C:8]1[C:17]([N+:18]([O-])=O)=[CH:16][CH:15]=[C:14]2[C:9]=1[CH2:10][CH2:11][CH2:12][NH:13]2)=[O:6])C>C(O)(=O)C.[Pd]>[CH2:21]([N:7]1[C:8]2[C:9]3[CH2:10][CH2:11][CH2:12][NH:13][C:14]=3[CH:15]=[CH:16][C:17]=2[NH:18][C:4](=[O:3])[C:5]1=[O:6])[CH2:22][CH2:23][CH3:24]

Participants

4

Reactant 1

HCID 53663592[Butyl(1,2,3,4-tetrahydro-6-nitro-5-quinolinyl)-amino]oxo-acetic Acid Ethyl Ester

Product 1

HCID 20633122HCID 20633122, compoundYield 71%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A solution of the product from Example 88 (0.63 g) in 75 mL of acetic acid was treated with 56 Pd/C (0.2 g) and shaken on a Parr apparatus under a hydrogen atmosphere (52 psi) for 12 hours. The catalyst was removed by filtration and the filtrate evaporated. The residue was washed with ether to give the title compound (0.35 g, 71% yield).

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated
  3. washThe residue was washed with ether

Sources & evidence

ORD record
ord-7ef201be0f5a416b828d947e63f1f096
Source dataset
uspto-grants-2004_03
Patent number
US06703391B2

Reaction notes

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