HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Methyl 2-(2-chloromethyl-5-chlorophenoxy)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Methyl 2-(5-chloro-2-hydroxymethylphenoxy)propionate | HCID 53695259 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2-(2-chloromethyl-5-chlorophenoxy)propionate | HCID 53768369 | 88% |
Reaction Steps
By the method of Example 1, Step H, 1.0 g (0.0038 mole) of methyl 2-(5-chloro-2-hydroxymethylphenoxy)propionate and 0.5 g (0.0042 mole) of thionyl chloride were reacted in 20 mL of methylene chloride. After purification, 0.88 g of methyl 2-(2-chloromethyl-5-chlorophenoxy)propionate was isolated as a yellow liquid. The NMR spectrum was consistent with the proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05798316 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-0564d9f77d574b5eaa8fc83dec2baed9 |
| Source note | uspto-grants-1998_08 |