反应详情

温度

40 °C

A 5.9 g quantity of diethyl 4-(4-hydroxyquinazolin-2-yl)benzylphosphonate, 1.8 g of potassium tert-butoxide and 2.3 g of methyl iodide were suspended in 100 ml of anhydrous methanol and stirred with heating at 40° C. for 16 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (eluent: methylene chloride: methanol=100:1) and the crude crystals thus obtained were recrystallized from methylene chloride-n-hexane to provide 3.0 g of the title compound as colorless crystals.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off under reduced pressure
3. customThe residue was purified by silica gel column chromatography (eluent: methylene chloride: methanol=100:1)
4. customthe crude crystals thus obtained
5. customwere recrystallized from methylene chloride-n-hexane