HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Amino-9-methyl-1,4,7,8,9,10-hexahydro-pyrido[3,4-f]quinoxaline-2,3-dione → 9-Methyl-2,3-dioxo-1,2,3,4,7,8,9,10-octahydro-pyrido[3,4-f]quinoxaline-6-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Amino-9-methyl-1,4,7,8,9,10-hexahydro-pyrido[3,4-f]quinoxaline-2,3-dione | HCID 9992119 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 9-Methyl-2,3-dioxo-1,2,3,4,7,8,9,10-octahydro-pyrido[3,4-f]quinoxaline-6-carbonitrile | HCID 10422535 | — |
Reaction Steps
The product from Example 79 is treated with sodium nitrite in 37% HCl solution at 0° C. The reaction mixture is poured into a solution of CuCN and the title compound is isolated by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06703391B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-54823148799a48c39c1cdf955319cd46 |
| Source note | uspto-grants-2004_03 |