HCID 15289365, compound → HCID 9952153, compound

HRID 482496Notes

Reaction equation

HRID 482496 reaction equation
[C:1]12([C:11]3[CH:12]=[C:13]([C:19]#[C:20][C:21]4[CH:30]=[CH:29][C:24]([C:25]([O:27]C)=[O:26])=[CH:23][CH:22]=4)[CH:14]=[CH:15][C:16]=3[O:17][CH3:18])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>[OH-].[Na+]>[C:1]12([C:11]3[CH:12]=[C:13]([C:19]#[C:20][C:21]4[CH:30]=[CH:29][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=4)[CH:14]=[CH:15][C:16]=3[O:17][CH3:18])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Participants

3

Reactant 1

HCID 15289365HCID 15289365, compound

Product 1

HCID 9952153HCID 9952153, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

966 mg (2.4 mmol) of the ester prepared in part (b) above and 20 ml of methanolic sodium hydroxide (2N) were introduced into a round-bottomed flask and heating was carried out at reflux for one hour. The reaction mixture was evaporated to dryness, the residue was taken up in water, acidification was carried out with concentrated hydrochloric acid and the solids which had precipitated were filtered.

Workup

  1. additionwere introduced into a round-bottomed flask
  2. temperatureheating
  3. temperatureat reflux for one hour
  4. customThe reaction mixture was evaporated to dryness
  5. customthe solids which had precipitated
  6. filtrationwere filtered

Sources & evidence

ORD record
ord-b509e3fd1a0349d7b60d5dac796c8a89
Source dataset
uspto-grants-1998_08
Patent number
US05798354

Reaction notes

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