Diethyl Ether → HCID 18980985, compound

Participants

Reaction Steps

To 25 g (222 mmole) of 2-propoxypropionitrile (Example 96b) in 100 ml of diethyl ether was dropwise added 200 ml (200 mmole) of 1.0M 4-chlorophenylmagnesium bromide. After refluxing for 30 minutes the reaction mixture was cautiously quenched with 20 ml of water followed by a mixture of 25 ml of sulfuric acid and 75 ml of water. After stirring for 30 minutes the organic layer was separated, washed with brine, dried over anhydrous magnesium sulfate, concentrated in vacuo, and distilled yielding 25.9 g of the title compound, bp 110°-125° C. at 0.3 torr.

Provenance & Evidence