2-Methylbenzenesulfonic acid → HCID 13644521, compound

HRID 482688Notes

Reaction equation

HRID 482688 reaction equation
O[CH:2]1[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[C:5]2([C:16](=[O:17])[NH:15][C:14](=[O:18])[NH:13]2)[CH2:4][CH2:3]1.C1(C)C(S(O)(=O)=O)=CC=CC=1>C1(C)C=CC=CC=1>[F:12][C:8]1[CH:7]=[C:6]2[C:11]([CH:2]=[CH:3][CH2:4][C:5]32[C:16](=[O:17])[NH:15][C:14](=[O:18])[NH:13]3)=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 69252-Methylbenzenesulfonic acidHCID 135630973',4'-dihydro-4'-hydroxy-7'-fluorospiro[imidazolidine-4,1'(2'H)-naphthalene]2,5-dione

Product 1

HCID 13644521HCID 13644521, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3',4',-Dihydro-4'-hydroxy-7'-fluorospiro[imidazolidine-4,1'(2'H)-naphthalene]2,5-dione (3.2 g., 0.013 mole) was added to 75 ml. of toluene containing a trace of -toluenesulfonic acid and the mixture heated to reflux for 5 hours. The toluene was removed in vacuo and the residue triturated with diethyl ether and filtered, 2.6 g. (87% yield).

Workup

  1. temperatureto reflux for 5 hours
  2. customThe toluene was removed in vacuo
  3. customthe residue triturated with diethyl ether
  4. filtrationfiltered

Sources & evidence

ORD record
ord-1f8ff5667a1c4f4c83ce958f46f003e5
Source dataset
uspto-grants-1986_03
Patent number
US04575507

Reaction notes

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