Hydrogen iodide → HCID 13644526, compound

Participants

Reaction Steps

A solution of 4.0 g. (0.0122 mole) of 4-(2'-methoxy-5'-chlorophenyl)-4-(carboethoxymethyl)imidazolidine 2,5-dione in 40 ml. of 58% hydriodic acid was heated to 115° C. for 4 hours. The reaction mixture was cooled, poured into water and extracted with ethyl acetate. The combined extracts were washed with a sodium bisulfite solution, water and brine, dried over magnesium sulfate and concentrated in vacuo to dryness. The residue was chromatographed using ethyl acetatehexane as the eluent (1:1; V:V) to give 106 mg. of product as the less polar material, m.p. 289°-290° C. (dec.).

Provenance & Evidence