Dimethylamine → HCID 13726314, compound

HRID 4827Notes

Reaction equation

HRID 4827 reaction equation
[CH2:1]([N:8]1[C:14](=[O:15])[C:13]2[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=2[O:11][CH:10]([CH2:20][CH2:21]Cl)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:23][NH:24][CH3:25]>>[OH2:11].[CH2:1]([N:8]1[C:14](=[O:15])[C:13]2[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=2[O:11][CH:10]([CH2:20][CH2:21][N:24]([CH3:25])[CH3:23])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 137262924-Benzyl-2-(2-chloroethyl)-2,3-dihydro-1,4-benzoxazepin-5(4H)-one

Product 1

HCID 13726314HCID 13726314, compound

Procedure

Following the procedure of Example 1, 4-benzyl-2-(2-chloroethyl)-2,3-dihydro-1,4-benzoxazepin-5(4H)-one and dimethylamine were reacted and the free base of the title compound was obtained in the concentrated residue. Recrystallization from ethanol-water gave the product, m.p. 75°-77° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c7bfc234f1744f32ad7ffb0232bfef78
Source dataset
uspto-grants-1988_02
Patent number
US04727152

Reaction notes

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