Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 482765Generated: October 30, 2026

Ethyl 2-amino-4-phenylbutanoate → 1-ethoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-one

https://huagongshe.com/reaction/482765

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 2-amino-4-phenylbutanoateHCID 4646380—
ReactantEthyl 2-(2,3-dioxo-4,5-dihydro-1-benzazepin-1-yl)acetateHCID 13500724—
Product1-ethoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-oneHCID 13243517—

Reaction Steps

Ethyl 2-amino-4-phenylbutyrate is treated under conditions of reductive alkylation as described in the previous examples with 1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepine-2,3-dione to give 1-ethoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-one of example 10.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04575503
Source datasetuspto-grants-1986_03
ORD IDord-7b76967d479b4648ae778860c1d01989
Source noteuspto-grants-1986_03