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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 482775Generated: October 30, 2026

Bromoacetonitrile → HCID 20244782, compound

https://huagongshe.com/reaction/482775

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBromoacetonitrileHCID 11534—
ReactantSodium hydrideHCID 24758—
ReactantHCID 9902422HCID 9902422—
SolventDimethylformamideHCID 6228—
ProductHCID 20244782HCID 20244782—

Reaction Steps

3-(1-carboxy-3-phenylpropylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one is alkylated with bromoacetonitrile in dimethylformamide solution in the presence of sodium hydride to yield after work-up, 3-(1-carboxy-3-phenylpropylamino)-1-cyanomethyl-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one, used directly in the next step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04575503
Source datasetuspto-grants-1986_03
ORD IDord-5648d8867897474695f667a55f186360
Source noteuspto-grants-1986_03