反应详情

温度

125 °C

Nitric acid (20 mL of 70%) was added to a hot (125° C.) solution of 7-fluoro-4-quinolinol (35 g, 214 mmol) in propionic acid (200 mL). The reaction mixture was stirred at 125° C. for about 1.5 hours and then allowed to cool to ambient temperature. The resulting yellow precipitate was isolated by filtration, rinsed with water and then with ethanol, and then recrystallized from N,N-dimethylformamide/water to provide 18 g of 7-fluoro-3-nitro-4-quinolinol.

1. temperatureto cool to ambient temperature
2. customThe resulting yellow precipitate was isolated by filtration
3. washrinsed with water
4. customwith ethanol, and then recrystallized from N,N-dimethylformamide/water