Potassium Hydroxide → HCID 20244002, compound

Participants

Reaction Steps

To a solution of 7.6 g of potassium hydroxide in 500 ml of methanol was added 37 g of the hydrochloride obtained in Example 3, and the mixture was stirred at room temperature for 2 hours. The insoluble substance was filtered off and the filtrate was concentrated. To the residue was added 2 liters of water and the mixture was stirred, and then the precipitated crystals were filtered with suction. After the crystals were recrystallized from a mixture of ethyl acetate and methanol, 12.5 g of the purified crystals were redissolved in 350 ml of methanol under heating. To the solution was added 8 ml of 18% hydrochloric acid and the mixture was cooled with ice. The precipitated crystals were filtered with suction to give 1-benzyl-5-hydroxy-2-methyl-N-(1-(2-phenylethyl)-4-piperidyl)indole-3-carboxamide hydrochloride as white crystals, melting at 210°-212° C.

Provenance & Evidence