Hydrochloric Acid → HCID 20244053, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 12 g of 3-carbomethoxy-4-carbethoxy-1-oxo-pyrido[2,1-C][1,4]benzothiazine in 270 ml 0.5N NaOH and 60 ml ethanol was stirred at 60° C. for 2 hrs. It was then acidified with 1N HCl, filtered, the precipitate washed with water and dried to give 8.5 g crude solid which was purified by dissolving in IN NaOH, and crystallizing out by addition of IN HCl. It was then filtered, washed with water and ether to give 7.8 g product, m.p. 222° C. (decomposition).

Provenance & Evidence