HCID 20244053, compound → HCID 20244060, compound

HRID 482869Notes

Reaction equation

HRID 482869 reaction equation
[O:1]=[C:2]1[C:7]2[N:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]3=[CH:10][S:11][C:6]=2[C:5](C(O)=O)=[C:4]([C:19]([OH:21])=[O:20])[CH2:3]1>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[O:1]=[C:2]1[C:7]2[N:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]3=[CH:10][S:11][C:6]=2[CH:5]=[C:4]([C:19]([OH:21])=[O:20])[CH2:3]1

Participants

3

Reactant 1

HCID 20244053HCID 20244053, compound

Product 1

HCID 20244060HCID 20244060, compoundYield 68.2%

Reagents, catalysts & solvents 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)Solvent

Conditions

Temperature
230 °C

Procedure

A mixture of 6 g of 1-oxo-pyrido[2,1-C][1,4]benzothiazine-3,4-dicarboxylic acid in 60 ml Dow-Therm-A was stirred at 230° C. for 1 hr. (until no more gas was evolved). It was then allowed to cool, filtered, and the precipitate washed with ether giving 4.1 g crude product which was crystallized from 1N NaOH and 1N HCl to give 3.5 g product, m.p. 222° C.

Workup

  1. temperatureto cool
  2. filtrationfiltered
  3. washthe precipitate washed with ether giving 4.1 g crude product which
  4. customwas crystallized from 1N NaOH and 1N HCl

Sources & evidence

ORD record
ord-a299d9e9efab4f85b8569db717ec0345
Source dataset
uspto-grants-1986_03
Patent number
US04576942

Reaction notes

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