4,4,4-Trifluoro-1-(pyridin-4-yl)butane-1,3-dione → 2-[4-(Phenylmethyl)-1-piperazinyl]-7-(4-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

Participants

Reaction Steps

A mixture of 3.9 g (0.014 moles) of 4,4,4-trifluoro-1-(4-pyridyl)-1,3-butanedione (U.S. Pat. No. 3,200,128), 3.9 g (0.014 moles) of 3-amino-5-(4-phenylmethyl-1-piperazinyl)-4-pyrazolecarbonitrile (prepared as described in Example 1) and 100 ml of glacial acetic acid was stirred at reflux for 16 hours.

Provenance & Evidence