Sodium Hydroxide → HCID 13579997, compound

Participants

Reaction Steps

A solution of 5,6,7,8-tetrahydro-2-methyl-3-quinolinecarboxylic acid ethyl ester (1.6 g) in methanol (25 ml) is treated with N sodium hydroxide (8 ml) and heated at reflux temperature for 4 hours. The solution is concentrated, diluted with water and the solution is extracted with ethyl acetate. The washed extract is dried and evaporated to a viscous residue which crystallizes after trituration with ether. Recrystallization of the product (0.119 g) from methanol-ethyl acetate solution gives pure 5,6,7,8-tetrahydro-2-methyl-3-quinolinecarboxylic acid, m.p. 196° C.-197° C.

Provenance & Evidence