Chlorine → HCID 13336486, compound

HRID 482910Notes

Reaction equation

HRID 482910 reaction equation
[CH3:1][NH:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1.[Cl:9]Cl>C(Cl)Cl.C(Cl)(Cl)(Cl)Cl>[CH3:1][NH:2][C:3]1[C:7]([Cl:9])=[C:6]([CH3:8])[O:5][N:4]=1

Participants

5

Reactant 2

HCID 24526ChlorineHCID 12580405N,5-Dimethyl-1,2-oxazol-3-amine

Product 1

HCID 13336486HCID 13336486, compoundYield 84.6%

Reagents, catalysts & solvents 2

HCID 5943Carbon TetrachlorideSolventHCID 6344DichloromethaneSolvent

Procedure

Compound (15) (19.06 g) was dissolved in methylene chloride (150 ml) and a solution of chlorine (13.1 g) in carbon tetrachloride (139 ml) was added thereto dropwise. The mixture was stirred at room temperature for 10 minutes, then washed with a 50% potassium carbonate solution and water, dried and evaporated to give 3-methylamino-4-chloro-5-methylisoxazole (20) (21.07 g); mp. 43°-47° C.

Workup

  1. washwashed with a 50% potassium carbonate solution and water
  2. customdried
  3. customevaporated

Sources & evidence

ORD record
ord-717f69be8dce46369d65d4da9bcfd252
Source dataset
uspto-grants-1986_03
Patent number
US04576956

Reaction notes

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