Potassium Carbonate → HCID 20243557, compound

Participants

Reaction Steps

4-Benzyloxyaniline hydrochloride (5.893 g, 25 mmol) was added to a solution of benzyl bromoacetate (4.0 ml, 25 mmol) in 25 ml of dry dimethylformamide. Sodium acetate (2.051 g, 25 mmole) and 13.82 g (0.1 mole) of potassium carbonate were added, and the reaction mixture was stirred at room temperature overnight. The reaction mixture was extracted from water with three portions of ethyl acetate. The combined organic layers were washed with water and dried over sodium sulfate. The volatiles were removed, and the residue was purified by flash column chromatography on silica (LPS-1) (eluting with 15% ethyl acetate/hexane) to yield 5.64 g of the title compound.

Provenance & Evidence