Water → HCID 20244216, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7.09 g (0.025 m) of 6,11-dihydro-α-methyl-11-oxodibenz[b,e]oxepin-2-acetic acid, and 2.59 g (0.0188 m) of anhydrous K2CO3 in 70 ml of dimethylformamide was warmed at 50° C. for one hour in an atmosphere of nitrogen. To this mixture 6.32 g (0.276 m) of benzyl bromoacetate was added dropwise and the mixture was held at 50° C. overnight (about 16 hours). The reaction mixture was poured into water and extracted with ether. The ether extract was washed with 5% NaHCO3, dried over Na2SO4, filtered and evaporated to give 10.11 g (94%) of an oil of (±)-2-phenylmethoxy-2-oxoethyl 6,11-dihydro-α-methyl-11-oxodibenz[b,e]oxepin-2-acetate.

Provenance & Evidence