3',5'-Dimethoxy-3,6-dihydro[1,1'-biphenyl]-2(1H)-one → 2-(3,5-Dimethoxyphenyl)cyclohexan-1-one

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Reaction Steps

A mixture of 23.6 g. 2-(3,5-dimethoxyphenyl)-4-cyclohexen-1-one, 300 ml. ethanol and 3 g. 10% Pd/C catalyst was hydrogenated at 40 psi (2.8 kg./cm.2). After hydrogen uptake ceased, the mixture was filtered, the filtrate evaporated in vacuo and the residue recrystallized from isopropyl ether to obtain 17 g. of product, M.P. 61°-62° C., lit. [J. Org. Chem., 27, 376 (1962)], M.P. 62.5°-63° C.

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