反应详情

A suspension of 4-hydroxy-7-methoxyquinoline-3-carboxylic acid (4.0 g) in Dowtherm A (75 mL) was heated at reflux for 2 hrs. The resulting brown solution was allowed to slowly cool to ambient temperature. The resulting precipitate was isolated by filtration and then dried in a vacuum oven at 80° C. for 2.5 days to provide 3.1 g of 7-methoxyquinolin-4-ol as a light tan solid.

1. temperaturewas heated
2. temperatureat reflux for 2 hrs
3. customThe resulting precipitate was isolated by filtration
4. customdried in a vacuum oven at 80° C. for 2.5 days