反应详情

To 80% formic acid (17 ml) was added 7β-[2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[(1-amino-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid (4.3 g, 5.7 mmol) with stirring at room temperature and the mixture was stirred for an hour and a quarter. After adding water (85 ml), the mixture was filtered to remove insoluble material and the filtrate was concentrated below 45° C. The residue was treated with tetrahydrofuran (10 ml)-ether (5 ml) and concentrated again under reduced pressure. The residue was treated with ether to give pale yellow substances of 7β-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[(1-amino-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid formate (2.98 g, 93.9%).

1. stirringthe mixture was stirred for an hour
2. filtrationthe mixture was filtered
3. customto remove insoluble material
4. concentrationthe filtrate was concentrated below 45° C
5. additionThe residue was treated with tetrahydrofuran (10 ml)-ether (5 ml)
6. concentrationconcentrated again under reduced pressure
7. additionThe residue was treated with ether