Sodium Bicarbonate → HCID 178486223, compound

Participants

Reaction Steps

A solution of sodium 7β-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-acetoxy-3-cephem-4-carboxylate (1.43 g, 3 mmol), 1-methylamino-5-mercapto-1H-tetrazole (0.590, 4.5 mmol) and sodium hydrogen carbonate (0.378 g, 4.5 mmol) in phosphate buffer (pH 6.4, 45 ml) was stirred at 60° C. for 8 hours. Then the solution was treated in a manner similar to that described in Example 7 to give pale yellow powder of sodium 7β-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[(1-methylamino-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylate (0.73 g, 44%).

Provenance & Evidence