HCID 13262012, compound → (6R,7R)-3-[(1-aminotetrazol-5-yl)sulfanylmethyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-propan-2-yloxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Participants

Reaction Steps

A solution of 7β-[2-(2-tritylaminothiazol-4-yl)-(Z)-2-isopropoxyiminoacetamido]-3-[(1-amino-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid (2.90 g, 3.7 mmol) in 80% formic acid (12 ml) was treated in a manner similar to that described in Example 6, (d) to give pale brown powder of 7β-[2-(2-aminothiazol-4-yl)-(Z)-2-isopropoxyiminoacetamido]-3-[(1-amino-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid (0.83 g, 41.5%).

Provenance & Evidence