反应详情

温度

10 °C

A 10.4 g (0.04 mole) quantity of 1-methyl-3-(3,4-dichlorophenyl)hydantoin was suspended in 80 ml of methanol. The suspension was cooled to 10° C. and 1.5 g of sodium borohydride was added thereto with stirring. After the addition, the mixture was stirred for 30 minutes and warmed to room temperature, followed by further agitation for 2 hours. After completion of the reaction, the reaction mixture was concentrated and water was added to the residue to deposit crystals. The crystals were filtered and recrystallized from ethanol, affording 9.2 g of white crystals in 88% yield.

1. additionAfter the addition
2. stirringthe mixture was stirred for 30 minutes
3. temperaturewarmed to room temperature
4. customAfter completion of the reaction
5. concentrationthe reaction mixture was concentrated
6. additionwater was added to the residue to deposit crystals
7. filtrationThe crystals were filtered
8. customrecrystallized from ethanol