4-Methoxy-6-methylpyrimidin-2-amine → HCID 13472238, compound

HRID 483057Notes

Reaction equation

HRID 483057 reaction equation
[CH2:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([S:10]([N:13]=[C:14]=[O:15])(=[O:12])=[O:11])[C:4]=2[CH2:3][O:2]1.[CH3:16][O:17][C:18]1[CH:23]=[C:22]([CH3:24])[N:21]=[C:20]([NH2:25])[N:19]=1>C(Cl)Cl>[CH3:16][O:17][C:18]1[CH:23]=[C:22]([CH3:24])[N:21]=[C:20]([NH:25][C:14]([NH:13][S:10]([C:9]2[C:4]3[CH2:3][O:2][CH2:1][C:5]=3[CH:6]=[CH:7][CH:8]=2)(=[O:12])=[O:11])=[O:15])[N:19]=1

Participants

4

Reactant 2

HCID 5872364-Methoxy-6-methylpyrimidin-2-amineHCID 13472237HCID 13472237, compound

Product 1

HCID 13472238HCID 13472238, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A 7.0 ml portion of the methylene chloride solution of 1,3-dihydrobenzo[c]furan-4-sulfonyl isocyanate prepared in Example 4 was added to a stirred suspension of 0.78 g of 4-methoxy-6-methylpyrimidin-2-amine in 20 ml of methylene chloride. After several minutes the amine dissolved, followed by formation of a precipitate. After stirring for 1.75 hours, the solid was collected, washed with methylene chloride and 1-chlorobutane, then dried to give 1.4 g of 1,3-dihydro-N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]benzo[c]furan-4-sulfonamide, m.p. 190°-194°(d).

Workup

  1. customthe solid was collected
  2. washwashed with methylene chloride and 1-chlorobutane
  3. customdried

Sources & evidence

ORD record
ord-aeeafb5abb074e0793ffe762c42bf055
Source dataset
uspto-grants-1986_03
Patent number
US04578108

Reaction notes

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