2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 3-Ethoxy-4-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-piperazin-1-yl]-1,2,5-thiadiazole-1-oxide

Participants

Reaction Steps

1.9 g (10 mMoles) of 3,4-diethoxy-1,2,5-thiadiazole-1-oxide are added to 2.9 g (10 mMoles) of 4-amino-6,7-dimethoxy-2-piperazinoquinazoline dissolved in 50 ml of tetrahydrofuran and 10 ml of methanol, followed by stirring for 5 hours at room temperature. The solid accumulating is separated off and recrystallized from 15 ml of dimethyl formamide and 10 ml of ethanol.

Provenance & Evidence