HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 483105Generated: November 1, 2026
Hydrochloric Acid → 5-Oxo-1,3-oxathiolane-4-carboxylic acid p-methoxybenzyl ester
https://huagongshe.com/reaction/483105
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | Carbonochloridic acid, (4-methoxyphenyl)methyl ester | HCID 13305526 | — |
| Reactant | 1,3-Oxathiolan-5-one | HCID 13474373 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Oxo-1,3-oxathiolane-4-carboxylic acid p-methoxybenzyl ester | HCID 54238544 | — |
Reaction Steps
A solution of lithium diisopropylamide prepared from diisopropylamine (3.1 ml), n-butyllithium (14 ml as 1.6M hexane solution) and tetrahydrofuran (40 ml) is cooled at -70° C., mixed with 5-oxo-1,3-oxathiolane (1.04 g) and p-methoxybenzyl chloroformate. After 30 minutes, the mixture is acidified with hydrochloric acid, concentrated, and extracted with ethyl acetate. The extract is washed with water, dried, and concentrated to give 5-oxo-1,3-oxathiolane-4-carboxylic acid p-methoxybenzyl ester (265 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04578378 |
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| Source dataset | uspto-grants-1986_03 |
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| ORD ID | ord-ca5ae94f2b6347ffbca113c1151d9aea |
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| Source note | uspto-grants-1986_03 |
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