HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 54211466, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | HCID 54552028 | HCID 54552028 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 54211466 | HCID 54211466 | 52.9% |
Reaction Steps
To a cold (-20° C.) solution of above 2-oxopiperazine-3-carboxylic acid ethyl ester (0.34 g) in tetrahydrofuran are dropwise added benzyl chloroformate (340 mg) and triethylamine (202 mg). After standing for 30 minutes the reaction mixture is concentrated in vacuum, diluted with ethyl acetate, and chromatographed to give oily 2-oxo-4-benzyloxycarbonylpiperazine-3-carboxylic acid ethyl ester (320 mg) as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04578378 |
| Source dataset | uspto-grants-1986_03 |
| ORD ID | ord-ce9cdce916874336a32d5b15725d1ac3 |
| Source note | uspto-grants-1986_03 |