2,6-Difluorobenzoyl isocyanate → HCID 13591680, compound

Participants

Reaction Steps

Into a 100 milliliter round bottom flask equipped with a thermometer, magnetic stirrer and condenser was added 30 milliliters of toluene, 1.2 grams (0.004 moles) of 2,5-dichloro-4-(alpha-cyano-4-fluorobenzyl)aniline prepared in Part B and 1.0 grams (0.005 moles) of 2,6-difluorobenzoyl isocyanate under a nitrogen atmosphere at ambient temperature. The reaction mixture was then heated in an oil bath for a period of 2 hours. After cooling to ambient temperature, the reaction mixture was filtered and dried overnight in a vacuum oven at 50° C. This afforded 1.3 grams of a white solid having a melting point of 216° C.-218° C. Elemental analysis of the white solid indicated the following:

Provenance & Evidence